Pennsylvania Route 199 is a 4.8-mile-long (7.7 km) state highway located in Bradford County in Pennsylvania. The southern terminus is at U.S. Route 220 near Athens. The northern terminus is the New York state line in Sayre, where it connects to New York State Route 34 and an interchange with Interstate 86 (I-86)/NY 17. PA 199 runs north–south through the Penn-York Valley communities of Athens and Sayre, following Main Street in Athens and Keystone Avenue, Mohawk Street, and Spring Street in Sayre. The section of PA 199 between the southern terminus and the intersection of Keystone Avenue and Mohawk Street in Sayre was designated as part of US 711 when the U.S. Highway System was created in 1926, being renumbered to US 220 a year later. Between 1930 and the 1960s, US 309 was concurrent with this portion of US 220. In the 1970s, US 220 was moved to a western bypass of the towns and PA 199 was designated onto its current alignment.

U.S. Route 220 is a U.S. Highway that is a spur route of US 20. It runs from Rockingham, North Carolina, north to South Waverly, Pennsylvania. In the state of Pennsylvania, the route runs 248 miles (399 km) from the Maryland border in Cumberland Valley Township, Bedford County northeast to an interchange with Interstate 86 (I-86)/New York State Route 17 in South Waverly, Bradford County a short distance south of the New York border. Through the state, US 220 passes through the cities and towns of Bedford, Altoona, State College, Lock Haven, Williamsport, and Towanda. US 220 is concurrent with the entire completed Pennsylvania segment of I-99 between I-70/I-76 in Bedford and near I-80 near Bellefonte. US 220 is also a freeway around Bedford, along the I-80 concurrency between Bellefonte and Mill Hall, between Mill Hall and Jersey Shore, from the western end of Williamsport to near Halls, and near the New York border. The remainder of US 220 in Pennsylvania is mostly a two-lane surface road.