Pennsylvania Route 488 is a 17-mile-long (27 km) state highway located in Lawrence and Butler counties in Pennsylvania. The western terminus is at PA 65/PA 288 in Ellwood City. The eastern terminus is at U.S. Route 422 in Moraine State Park.

Lawrence County is a county in the Commonwealth of Pennsylvania. As of the 2020 census, the population was 86,070. The county seat and largest city is New Castle.