The Philadelphia to Harrisburg Main Line is a rail line owned and operated by Amtrak in the U.S. state of Pennsylvania. This is the only electrified Amtrak line in the United States outside of the main line of the Northeast Corridor. The line runs from Philadelphia, where it meets the Northeast Corridor at Zoo Junction at milepost 1.9, west to Harrisburg, where electrification ends. The Main Line is part of the longer Keystone Corridor, which continues west to Pittsburgh along the Norfolk Southern Railway's Pittsburgh Line. This section is sometimes referred to as "Keystone East" and is part of Amtrak's Keystone Service.

The Keystone Corridor is a 349-mile (562 km) railroad corridor between Philadelphia and Pittsburgh, Pennsylvania, that consists of two rail lines: Amtrak and SEPTA's Philadelphia-to-Harrisburg main line, which hosts SEPTA's Paoli/Thorndale Line commuter rail service, and Amtrak's Keystone Service and Pennsylvanian inter-city trains; and the Norfolk Southern Pittsburgh Line. The corridor was originally the Main Line of the Pennsylvania Railroad.