Pickens County is located in the northwest part of the U.S. state of South Carolina. As of the 2020 census, its population was 131,404. Its county seat is Pickens. The county was created in 1826. It is part of the Greenville-Anderson-Greer, SC Metropolitan Statistical Area.

The Upstate, historically known as the Upcountry, is a region of the U.S. state of South Carolina, comprising the northwesternmost area of the state. Although loosely defined among locals, the general definition includes the 10 counties of the commerce-rich I-85 corridor in the northwest corner of South Carolina. This definition coincided with the Greenville-Spartanburg-Anderson, SC Combined Statistical Area, as first defined by the Office of Management and Budget (OMB) in 2015. In 2023, the OMB issued its most updated definition of the CSA that coincides again with the 10-county region.