Pico Boulevard is a major Los Angeles street that runs from the Pacific Ocean at Appian Way in Santa Monica to Central Avenue in Downtown Los Angeles, California, United States. It is named after Pío Pico, the last Mexican governor of Alta California.

Don Pío de Jesús Pico IV was a Californio politician, ranchero, and entrepreneur, famous for serving as the last governor of Alta California under Mexican rule. A member of the prominent Pico family of California, he was one of the wealthiest men in California at the time and a hugely influential figure in Californian society, continuing as a citizen of the nascent U.S. state of California. His legacy can be seen in the numerous places named after him, such as the city of Pico Rivera, Pico Boulevard in Los Angeles, Pio Pico State Historic Park, and numerous schools that bear his name.