Ponce de Leon Avenue, often simply called Ponce, provides a link between Atlanta, Decatur, Clarkston, and Stone Mountain, Georgia. It was named for Ponce de Leon Springs, in turn from explorer Juan Ponce de León, but is not pronounced as in Spanish. Several grand and historic buildings are located on the avenue.

Ponce de Leon Springs was a mineral spring in Atlanta, Georgia, in the United States. The spring was a popular tourist destination from the mid-1800s through the early 1900s. Around the turn of the century, the land surrounding the spring was developed into an amusement park. By the 1920s, the amusement park was demolished, and the area was developed for industrial and, later, commercial properties.