Ponce de Leon Avenue, often simply called Ponce, provides a link between Atlanta, Decatur, Clarkston, and Stone Mountain, Georgia. It was named for Ponce de Leon Springs, in turn from explorer Juan Ponce de León, but is not pronounced as in Spanish. Several grand and historic buildings are located on the avenue.

Ponce City Market is a mixed-use development located in a former Sears catalogue facility in Atlanta, with national and local retail anchors, restaurants, a food hall, boutiques and offices, and residential units. It is located adjacent to the intersection of the BeltLine with Ponce de Leon Avenue in the Old Fourth Ward near Virginia Highland, Poncey-Highland and Midtown neighborhoods. The 2.1-million-square-foot (200,000 m2) building, one of the largest by volume in the Southeast United States, was used by Sears, Roebuck and Co. from 1926 to 1987 and later by the City of Atlanta as "City Hall East". The building's lot covers 16 acres (65,000 m2). Ponce City Market officially opened on August 25, 2014. It was listed on the National Register of Historic Places in 2016.