The Port of San Francisco is a semi-independent organization that oversees the port facilities at San Francisco, California, United States. It is run by a five-member commission, appointed by the Mayor and approved by the Board of Supervisors. The Port is responsible for managing the larger waterfront area that extends from the anchorage of the Golden Gate Bridge, along the Marina district, all the way around the north and east shores of the city of San Francisco including Fisherman's Wharf and the Embarcadero, and southward to the city line just beyond Candlestick Point. In 1968, the State of California, via the California State Lands Commission for the State-operated San Francisco Port Authority, transferred its responsibilities for the Harbor of San Francisco waterfront to the City and County of San Francisco / San Francisco Harbor Commission through the Burton Act AB2649. All eligible State port authority employees had the option to become employees of the City and County of San Francisco to maintain consistent operation of the Port of San Francisco.

San Francisco, officially the City and County of San Francisco, is a commercial, financial, and cultural center in Northern California. With a population of 808,437 residents as of 2022, San Francisco is the fourth most populous city in the U.S. state of California. The city covers a land area of 46.9 square miles at the end of the San Francisco Peninsula, making it the second-most densely populated large U.S. city after New York City and the fifth-most densely populated U.S. county, behind only four New York City boroughs. Among the 92 U.S. cities proper with over 250,000 residents, San Francisco is ranked first by per capita income and sixth by aggregate income as of 2022.