Prentiss County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 25,008. Its county seat is Booneville. The county is named for Seargent Smith Prentiss, a noted speaker and US Congressman from Natchez.

Booneville is a city in the U.S. state of Mississippi and is the county seat of Prentiss County. It is located in the hilly North Mississippi region, and ecologically is part of the Southeastern Plains region.