Prescott Sheldon Bush Sr. was an American banker and Republican Party politician. After working as a Wall Street executive investment banker, he represented Connecticut in the United States Senate from 1952 to 1963. A member of the Bush family, he was the father of President George H. W. Bush, and the paternal grandfather of President George W. Bush and Florida Governor Jeb Bush.

The Bush family, also known as the Bush dynasty, is an American political family that has played a prominent role in American politics since the 1950s, foremost as the first family of the United States from 1989 to 1993 and again from 2001 to 2009, during the respective presidencies of George H.W. Bush and George W. Bush. They also played prominent roles in areas of American news, sports, entertainment, and business. They were also the second family of the United States from 1981 to 1989, when George H. W. Bush was vice president. The Bush family is one of four families to have produced two presidents of the United States by the same surname; the others were the Adams, Roosevelt, and Harrison families.