Refugio County is a county located in the U.S. state of Texas. As of the 2020 census, its population was 6,741. Its county seat is Refugio. The county originated as a municipality of Mexico in 1834 and was classified as a county in 1837.

Refugio is a town in Refugio County, of which it is the county seat, in the U.S. state of Texas. The population was 2,890 as of the 2010 Census. Refugio is the birthplace of Baseball Hall of Fame member Nolan Ryan.