The sack of Antwerp, often known as the Spanish Fury at Antwerp, was an episode of the Eighty Years' War. It is the greatest massacre in the history of the Low Countries.

A Spanish Fury was a number of violent sackings of cities in the Low Countries or Benelux, mostly by Spanish Habsburg armies, that happened in the years 1572–1579 during the Dutch Revolt. In some cases, the sack did not follow the taking of a city. In others, the sack was ordered, or at least not restrained, by Spanish commanders after the fall of a city.