Sam Houston Tollway Ship Channel Bridge is a span in Harris County, Texas. It was acquired from the then–Texas Turnpike Authority (TTA) on May 5, 1994, and is now a part of the Harris County Toll Road Authority system. The bridge opened to traffic in May 1982 and carries four lanes of the Sam Houston Tollway over the Houston Ship Channel with a clearance of 175 feet (53 m).

The Houston Ship Channel, in Houston, Texas, is part of the Port of Houston, one of the busiest seaports in the world. The channel is the conduit for ocean-going vessels between Houston-area terminals and the Gulf of Mexico, and it serves an increasing volume of inland barge traffic.