Samuel King Allison was an American physicist, most notable for his role in the Manhattan Project, for which he was awarded the Medal for Merit. A professor who studied X-rays, he was director of the Metallurgical Laboratory from 1943 until 1944, and later worked at the Los Alamos Laboratory — where he "rode herd" on the final stages of the project as part of the "Cowpuncher Committee", and read the countdown for the detonation of the Trinity nuclear test. After the war, he returned to the University of Chicago to direct the Institute for Nuclear Studies and was involved in the "scientists' movement", lobbying for civilian control of nuclear weapons.

The Metallurgical Laboratory was a scientific laboratory at the University of Chicago that was established in February 1942 to study and use the newly discovered chemical element plutonium. It researched plutonium's chemistry and metallurgy, designed the world's first nuclear reactors to produce it, and developed chemical processes to separate it from other elements. In August 1942 the lab's chemical section was the first to chemically separate a weighable sample of plutonium, and on 2 December 1942, the Met Lab produced the first controlled nuclear chain reaction, in the reactor Chicago Pile-1, which was constructed under the stands of the university's old football stadium, Stagg Field.