Samuel Austin Worcester, was an American missionary to the Cherokee, translator of the Bible, printer, and defender of the Cherokee sovereignty. He collaborated with Elias Boudinot (Cherokee) in Georgia to establish the Cherokee Phoenix, the first Native American newspaper, which was printed in both English and the Cherokee syllabary. The Cherokee gave Worcester the honorary name A-tse-nu-sti, which translates to "messenger" in English.

The Cherokee people are one of the Indigenous peoples of the Southeastern Woodlands of the United States. Prior to the 18th century, they were concentrated in their homelands, in towns along river valleys of what is now southwestern North Carolina, southeastern Tennessee, southwestern Virginia, edges of western South Carolina, northern Georgia and northeastern Alabama consisting of around 40,000 square miles