The Santa Ana Regional Transportation Center is a passenger rail station and transportation center in Santa Ana, California. It is used by Amtrak's Pacific Surfliner and Metrolink's Orange County Line and Inland Empire–Orange County Line trains. It is also a Greyhound station and a hub for the Orange County Transportation Authority bus system as well as a terminal for international bus services to Mexico.

Santa Ana is a city in and the county seat of Orange County, California, United States. Located in the Greater Los Angeles region of Southern California, the city's population was 310,227 at the 2020 census, making Santa Ana the second most populous city in Orange County, the 13th-most populous city in California, and the 64th densest large city in the United States. Santa Ana is a major regional economic and cultural hub for the Orange Coast.