The Basilica of the Holy Cross in Jerusalem or Basilica di Santa Croce in Gerusalemme is a Catholic Minor basilica and titular church in rione Esquilino, Rome, Italy. It is one of the Seven Pilgrim Churches of Rome.

Esquilino is the 15th rione, or administrative division, of Rome, Italy, identified by the initials R. XV, and is Located within the Municipio I. It is named after the Esquiline Hill, one of the Seven Hills of Rome.