Santa Fe is a business district and edge city in the west of Mexico City. It is part of the alcaldías (boroughs) of Cuajimalpa and Álvaro Obregón. Santa Fe consists mainly of luxury highrise buildings surrounding Centro Santa Fe, which is the largest mall in Latin America. The district includes a residential area and three university campuses.

Cuajimalpa de Morelos is a borough in Mexico City. It is located on the west side of the city in the Sierra de las Cruces mountains which separate Mexico City from the State of Mexico. The borough is named after the former rural town of Cuajimalpa, which has since been absorbed by urban sprawl. The borough is home to the Desierto de los Leones National Park, the first declared in Mexico as well as the second largest annual passion play in Mexico City.