The Second Battle of Homs was fought in western Syria on 29 October 1281, between the armies of the Mamluk dynasty of Egypt and the Ilkhanate, a division of the Mongol Empire centered on Iran. The battle was part of Abaqa Khan's attempt at taking Syria from the Egyptians.

The Ilkhanate or Il-khanate, ruled by the Il-Khans or Ilkhanids, and known to the Mongols as Hülegü Ulus, was a Mongol khanate established from the southwestern sector of the Mongol Empire. The Ilkhanid realm was officially known as the Land of Iran or simply Iran. It was established after Hülegü, the son of Tolui and grandson of Genghis Khan, inherited the West Asian part of the Mongol Empire after his brother Möngke Khan died in 1259.