The second deputy prime minister of Spain, officially Second Vice President of the Government of Spain, is a senior member of the Government of Spain. The office of the Second Deputy Prime Minister is defined in the Constitution but is not a permanent position, existing only at the discretion of the Prime Minister.

Yolanda Díaz Pérez is a Spanish politician and labour lawyer, currently serving as Second Deputy Prime Minister since 2021, and Minister of Labour and Social Economy of the Government of Spain since 2020. A member of the Congress of Deputies since 2016, she has previously been a Ferrol municipal councillor (2003–2012) and member of the Parliament of Galicia (2012–2016). She was the National Coordinator of Esquerda Unida (EU) from 2005 to 2017. In 2023, she founded the electoral platform Sumar, which she currently leads.