Shadow of the Vampire is a 2000 independent period vampire mystery film directed by E. Elias Merhige and written by Steven Katz. The film stars John Malkovich and Willem Dafoe. It is a fictionalized account of the making of the classic vampire film Nosferatu, eine Symphonie des Grauens, directed by F. W. Murnau, during which the film crew begin to have disturbing suspicions about their lead actor.

Vampire films have been a staple in world cinema since the era of silent films, so much so that the depiction of vampires in popular culture is strongly based upon their depiction in films throughout the years. The most popular cinematic adaptation of vampire fiction has been from Bram Stoker's 1897 novel Dracula, with over 170 versions to date. Running a distant second are adaptations of the 1872 novel Carmilla by Sheridan Le Fanu. By 2005, the Dracula character had been the subject of more films than any other fictional character except Sherlock Holmes.