Sherbrooke is a city in southern Quebec, Canada. It is at the confluence of the Saint-François and Magog rivers in the heart of the Estrie administrative region. Sherbrooke is also the name of a territory equivalent to a regional county municipality (TE) and census division (CD) of Quebec, coextensive with the city of Sherbrooke. With 172,950 residents at the Canada 2021 Census, it is the sixth largest city in the province and the 30th largest in Canada. The Sherbrooke Census Metropolitan Area had 227,398 inhabitants, making it the fourth largest metropolitan area in Quebec and 19th in Canada.

The Saint-François River is a right tributary of the St. Lawrence River in Quebec, Canada.