The Sherman–Denison metropolitan statistical area, as defined by the United States Census Bureau, is an area consisting of one county—Grayson—in North Texas, anchored by the cities of Sherman and Denison. According to the 2010 U.S. census, the MSA had a population of 120,877; according to 2021 estimates, it had a population of 139,336. The Sherman–Denison MSA is a component of the Dallas-Ft. Worth combined statistical area, which covers a 19-county area and had an estimated population of 8,057,796 as of July 1, 2009. It is also a major part of the Texoma region with proximity to both Lake Texoma and the Red River.

Grayson County is a county in the U.S. state of Texas. As of the 2020 census, its population was 135,543. The county seat is Sherman. The county was founded in 1846 and is named after Peter Wagener Grayson, an attorney general of the Republic of Texas. Grayson County is included in the Sherman-Denison metropolitan statistical area, which is also included in the Dallas-Fort Worth-Arlington, combined statistical area. Located on the state's border with Oklahoma, it is part of the Texoma region, with proximity to Lake Texoma and the Red River.