The Shire of Murrindindi is a local government area in the Hume region of Victoria, Australia, located in the north-east part of the state. It covers an area of 3,880 square kilometres (1,500 sq mi) and, in August 2021, had a population of 15,197. It includes the towns of Alexandra, Buxton, Eildon, Flowerdale, Kinglake, Marysville, Molesworth, Strath Creek, Taggerty, Yarck and Yea. It was formed in 1994 from the amalgamation of the Shire of Alexandra, Shire of Yea, and parts of the Shire of Broadford, Shire of Eltham, Shire of Euroa, Shire of Healesville and City of Whittlesea.

The Hume is an economic rural region located in the north-eastern part of Victoria, Australia. Comprising an area in excess of 40,000 square kilometres (15,000 sq mi) with a population that has grown from 263,000 to 309,684, the Hume region includes the local government areas of Alpine Shire, Rural City of Benalla, City of Wodonga, City of Greater Shepparton, Shire of Indigo, Shire of Mansfield, Shire of Strathbogie, Shire of Towong and the Rural City of Wangaratta, and also includes five unincorporated areas encompassing the alpine ski resorts in the region.