The Shire of Northern Grampians is a local government area in the Wimmera region of Victoria, Australia, located in the western part of the state. It covers an area of 5,730 square kilometres (2,210 sq mi) and in June 2018 had a population of 11,431, having fallen from 12,087 in 2008. It includes the city of Stawell and the towns of St Arnaud, Great Western, Marnoo, Glenorchy, Stuart Mill, Navarre and the tourist town of Halls Gap. It was formed in 1995 from the amalgamation of the City of Stawell, Town of St Arnaud, Shire of Stawell, Shire of Kara Kara and parts of the Shire of Wimmera, Shire of Dunmunkle and Shire of Donald.

The Victorian government's Wimmera Southern Mallee subregion is part of the Grampians region in western Victoria. It includes most of what is considered the Wimmera, and part of the southern Mallee region. The subregion is based on the social catchment of Horsham, its main settlement.