Sigma is the eighteenth letter of the Greek alphabet. In the system of Greek numerals, it has a value of 200. In general mathematics, uppercase Σ is used as an operator for summation. When used at the end of a letter-case word, the final form (ς) is used. In Ὀδυσσεύς (Odysseus), for example, the two lowercase sigmas (σ) in the center of the name are distinct from the word-final sigma (ς) at the end. The Latin letter S derives from sigma while the Cyrillic letter Es derives from a lunate form of this letter.

Letter case is the distinction between the letters that are in larger uppercase or capitals and smaller lowercase in the written representation of certain languages. The writing systems that distinguish between the upper- and lowercase have two parallel sets of letters: each in the majuscule set has a counterpart in the minuscule set. Some counterpart letters have the same shape, and differ only in size, but for others the shapes are different. The two case variants are alternative representations of the same letter: they have the same name and pronunciation and are typically treated identically when sorting in alphabetical order.