Making the sign of the cross, or blessing oneself or crossing oneself, is a ritual blessing made by members of some branches of Christianity. This blessing is made by the tracing of an upright cross or Greek cross across the body with the right hand, often accompanied by spoken or mental recitation of the Trinitarian formula: "In the name of the Father, and of the Son, and of the Holy Spirit. Amen."

The Christian cross, seen as a representation of the crucifixion of Jesus on a large wooden cross, is a symbol of Christianity. It is related to the crucifix and to the more general family of cross symbols, the term cross itself being detached from the original specifically Christian meaning in modern English.