The Siskiyou Mountains are a coastal subrange of the Klamath Mountains, and located in northwestern California and southwestern Oregon in the United States. They extend in an arc for approximately 100 miles (160 km) from east of Crescent City, California, northeast along the north side of the Klamath River into Josephine and Jackson counties in Oregon. The mountain range forms a barrier between the watersheds of the Klamath River to the south and the Rogue River to the north. Accordingly, much of the range is within the Rogue River – Siskiyou and Klamath national forests, and the Pacific Crest Trail follows a portion of the crest of the Siskiyous.

The Pacific Coast Ranges are the series of mountain ranges that stretch along the West Coast of North America from Alaska south to Northern and Central Mexico. Although they are commonly thought to be the westernmost mountain range of the continental United States and Canada, the geologically distinct Insular Mountains of Vancouver Island lie farther west.