A sistrum is a musical instrument of the percussion family, a form of rattle, used most notably by the ancient Egyptians. It consists of a handle and a U-shaped metal frame, made of brass or bronze and ranging from 30–76 cm (12–30 in) in width. The frame supports sliding metal cross-bars which may hold metal rings. When shaken, the small rings or loops of thin metal on its movable crossbars produce a sound that can vary from a soft clank to a loud jangling. Its name in the ancient Egyptian language was sekhem (sḫm) or sesheshet (sššt) because of the sound it made when it rattled.The ancient Egyptian sistrum had important associations with religious and ritualistic practices concerning various musical and joyful deities.

A musical instrument is a device created or adapted to make musical sounds. In principle, any object that produces sound can be considered a musical instrument—it is through purpose that the object becomes a musical instrument. A person who plays a musical instrument is known as an instrumentalist. The history of musical instruments dates to the beginnings of human culture. Early musical instruments may have been used for rituals, such as a horn to signal success on the hunt, or a drum in a religious ceremony. Cultures eventually developed composition and performance of melodies for entertainment. Musical instruments evolved in step with changing applications and technologies.