The Skeena River is the second-longest river entirely within British Columbia, Canada. Since ancient times, the Skeena has been an important transportation artery, particularly for the Tsimshian and the Gitxsan—whose names mean "inside the River of Mist" ,and "people of the River of Mist," respectively. The river and its basin sustain a wide variety of fish, wildlife, and vegetation, and communities native to the area depend on the health of the river. The Tsimshian migrated to the Lower Skeena River, and the Gitxsan occupy territory of the Upper Skeena.

The Tsimshian are an Indigenous people of the Pacific Northwest Coast of North America. Their communities are mostly in coastal British Columbia in Terrace and Prince Rupert, and Metlakatla, Alaska on Annette Island, the only reservation in Alaska.