Sonoma Creek is a 33.4-mile-long (53.8 km) stream in northern California. It is one of two principal drainages of southern Sonoma County, California, with headwaters rising in the rugged hills of Sugarloaf Ridge State Park and discharging to San Pablo Bay, the northern arm of San Francisco Bay. The watershed drained by Sonoma Creek is roughly equivalent to the wine region of Sonoma Valley, an area of about 170 square miles (440 km2). The State of California has designated the Sonoma Creek watershed as a “Critical Coastal Water Resource”. To the east of this generally rectangular watershed is the Napa River watershed, and to the west are the Petaluma River and Tolay Creek watersheds.

Sonoma County is located in the U.S. state of California. As of the 2020 United States Census, its population was 488,863. Its seat of government and largest city is Santa Rosa.