South Carolina is a state in the coastal Southeastern region of the United States. It borders North Carolina to the north, the Atlantic Ocean to the southeast, and Georgia to the southwest across the Savannah River. Along with North Carolina, it makes up the Carolinas region of the East Coast. South Carolina is the 40th-largest and 23rd-most populous U.S. state with a recorded population of 5,118,425 according to the 2020 census. In 2019, its GDP was $213.45 billion. South Carolina is composed of 46 counties. The capital is Columbia with a population of 136,632 in 2020; while its most populous city is Charleston with a 2020 population of 150,227. The Greenville-Spartanburg-Anderson, SC Combined Statistical Area is the most populous combined metropolitan area in the state, with an estimated 2023 population of 1,590,636.

The Southeastern United States, also referred to as the American Southeast, the Southeast, or the South, is a geographical region of the United States located in the eastern portion of the Southern United States and the southern portion of the Eastern United States. The region includes a core of states that reaches north to Maryland and West Virginia, bordering the Ohio River and Mason–Dixon line, and stretches west to Arkansas and Louisiana.