South Philadelphia High School is a public secondary high school located in the Lower Moyamensing neighborhood of South Philadelphia, at the intersection of Broad Street and Snyder Avenue.

Lower Moyamensing is a neighborhood in South Philadelphia, Pennsylvania, United States, situated just south of the East Passyunk Crossing neighborhood and north of the stadium area. It is bounded by Snyder Avenue to the north, Oregon Avenue to the south, South 7th Street to the east, and South Broad Street to the west. The neighborhood was once part of Moyamensing Township before becoming part of Philadelphia in 1854. Lower Moyamensing is known for its 19th century row homes, factory buildings, and variety of restaurants. South Philadelphia High School is located in Lower Moyamensing, at the corner of Broad and Jackson Streets.