The Soyuz-TMA is a spacecraft used by the Russian Federal Space Agency for human spaceflight. It is a revision of the Soyuz spacecraft and was superseded in 2010 by the Soyuz TMA-M.(T – транспортный – Transportnyi – meaning transport, M – модифицированный – Modifitsirovannyi – meaning modified, A – антропометрический, – Antropometricheskii meaning anthropometric). The spacecraft features several changes to accommodate requirements requested by NASA in order to service the International Space Station, including more latitude in the height and weight of the crew and improved parachute systems. It is also the first expendable vehicle to feature a "glass cockpit". Soyuz-TMA looks identical to the earlier Soyuz-TM spacecraft on the outside, but interior differences allow it to accommodate taller occupants with new adjustable crew couches.

Soyuz is a series of spacecraft which has been in service since the 1960s, having made more than 140 flights. It was designed for the Soviet space program by the Korolev Design Bureau. The Soyuz succeeded the Voskhod spacecraft and was originally built as part of the Soviet crewed lunar programs. It is launched on a Soyuz rocket from the Baikonur Cosmodrome in Kazakhstan. Between the 2011 retirement of the Space Shuttle and the 2020 demo flight of SpaceX Crew Dragon, the Soyuz served as the only means to ferry crew to or from the International Space Station, for which it remains heavily used. Although China did launch crewed Shenzhou flights during this time, none of them docked with the ISS.