SpaceX CRS-5, also known as SpX-5, was a Commercial Resupply Service mission to the International Space Station (ISS), conducted by SpaceX for NASA, and was launched on 10 January 2015 and ended on 11 February 2015. It was the seventh flight for SpaceX's uncrewed Dragon cargo spacecraft and the fifth SpaceX operational mission contracted to NASA under an ISS resupply services contract.

Commercial Resupply Services (CRS) are a series of flights awarded by NASA for the delivery of cargo and supplies to the International Space Station (ISS) on commercially operated spacecraft. The first CRS contracts were signed in 2008 and awarded $1.6 billion to SpaceX for twelve cargo Dragon and $1.9 billion to Orbital Sciences for eight Cygnus flights, covering deliveries to 2016. The Falcon 9 and Antares rockets were also developed under the CRS program to deliver cargo spacecraft to the ISS.