The Space Launch System (SLS) is an American super heavy-lift expendable launch vehicle used by NASA. As the primary launch vehicle of the Artemis Moon landing program, SLS is designed to launch the crewed Orion spacecraft on a trans-lunar trajectory. The first SLS launch was the uncrewed Artemis 1, which took place on 16 November 2022.

An expendable launch system is a launch vehicle that can be launched only once, after which its components are either destroyed during reentry or discarded in space. ELVs typically consist of several rocket stages that are discarded sequentially as their fuel is exhausted and the vehicle gains altitude and speed. As of 2024, less and less satellites and human spacecraft are launched on ELVs in favor of reusable launch vehicles. However, there are many instances where a ELV may still have a compelling use case over a reusable vehicle. ELVs are simpler in design than reusable launch systems and therefore may have a lower production cost. Furthermore, an ELV can use its entire fuel supply to accelerate its payload, offering greater payloads. ELVs are proven technology in widespread use for many decades.