Spain competed at the 2012 Summer Olympics in London, from 27 July to 12 August 2012. This nation has competed in all but two Summer Olympic Games since its official debut in 1920. Spain boycotted two editions, the 1936 Summer Olympics in Nazi Germany and the 1956 Summer Olympics in Melbourne, as a protest against the Soviet invasion of Hungary. In 2012, the Spanish Olympic Committee sent the nation's smallest delegation to the Games since 1988. A total of 278 athletes, 166 men and 112 women, competed in 23 sports.

The men's singles table tennis event was part of the table tennis programme at the 2012 Summer Olympics in London. The event took place from Saturday 28 July to Thursday 2 August 2012 at ExCeL London. The tournament was a single elimination tournament with a third place playoff played between the two losing semi-finalists. In the 2008 event all three medals were won by Chinese athletes with Ma Lin taking gold.