Spain competed at the 2012 Summer Olympics in London, from 27 July to 12 August 2012. This nation has competed in all but two Summer Olympic Games since its official debut in 1920. Spain boycotted two editions, the 1936 Summer Olympics in Nazi Germany and the 1956 Summer Olympics in Melbourne, as a protest against the Soviet invasion of Hungary. In 2012, the Spanish Olympic Committee sent the nation's smallest delegation to the Games since 1988. A total of 278 athletes, 166 men and 112 women, competed in 23 sports.

The women's 75 kilograms weightlifting event at the 2012 Summer Olympics in London, United Kingdom, took place at ExCeL London on 3 August 2012.