During the Spanish colonization of the Americas, the Spanish Main was the collective term for the parts of the Spanish Empire that were on the mainland of the Americas and had coastlines on the Caribbean Sea or Gulf of Mexico. The term was used to distinguish those regions from the numerous islands Spain controlled in the Caribbean, which were known as the Spanish West Indies.

Portobelo is a historic port and corregimiento in Portobelo District, Colón Province, Panama. Located on the northern part of the Isthmus of Panama, it is 32 km (20 mi) northeast of the modern port of Colón now at the Atlantic entrance to the Panama Canal. It has a population of 4,559 as of 2010, and functions as the seat of Portobelo District.