The Spanish conquest of Honduras was a 16th-century conflict during the Spanish colonization of the Americas in which the territory that now comprises the Republic of Honduras, one of the seven states of Central America, was incorporated into the Spanish Empire. In 1502, the territory was claimed for the king of Spain by Christopher Columbus on his fourth and final trip to the New World. The territory that now comprises Honduras was inhabited by a mix of indigenous peoples straddling a transitional cultural zone between Mesoamerica to the northwest, and the Intermediate Area to the southeast. Indigenous groups included Maya, Lenca, Pech, Miskitu, Mayangna (Sumu), Jicaque, Pipil and Chorotega. Two indigenous leaders are particularly notable for their resistance against the Spanish; the Maya leader Sicumba, and the Lenca ruler referred to as Lempira.

Lempira was a warrior, chieftain of the Lencas of western Honduras in Central America during the 1530s, when he led resistance to Francisco de Montejo's attempts to conquer and incorporate the region into the province of Honduras. Mentioned as Lempira in documents written during the Spanish conquest, he is regarded by the people as a warrior hero whom the conquistadors feared, since they could not kill him. The Spaniards sent a messenger to tell him they wanted “peace”, but when Lempira showed up for negotiations, they captured him, dismembered his body, and buried him in undisclosed locations so no one could pay him respects.