"Brand New Day" is a comic book storyline in The Amazing Spider-Man, published by Marvel Comics beginning in 2008. It chronicles the start of Spider-Man's adventures in the aftermath of the status quo-altering "One More Day" storyline, and continues afterwards into "Spider-Man: Big Time". Although the banner only runs across the front covers of #546-564 and the Spider-Man: Swing Shift one-shot, "Brand New Day" is also used to refer to the entire 102-issue run of stories featured in Amazing Spider-Man #546-647 and accompanying tie-in series, one-shots, and annuals.

The Amazing Spider-Man is an ongoing American superhero comic book series featuring the Marvel Comics superhero Spider-Man as its title character and main protagonist. Being in the mainstream continuity of the franchise, it was the character's first title, launching seven months after his introduction in the final issue of Amazing Fantasy. The series began publication with a March 1963 cover date and has been published nearly continuously to date over six volumes with only one significant interruption. Issues of the title currently feature an issue number within its sixth volume, as well as a "legacy" number reflecting the issue's overall number across all Amazing Spider-Man volumes. The title reached 900 issues in 2022.