The St. James Building is a historic building in Downtown Jacksonville, Florida, currently housing Jacksonville City Hall. It was designed by architect Henry John Klutho and opened in 1912. One of many structures in downtown Jacksonville designed by Klutho after the Great Fire of 1901, it is considered his Prairie School masterpiece.

Downtown Jacksonville is the historic core and central business district (CBD) of Jacksonville, Florida. It comprises the earliest area of the city to be developed and is located in its geographic center along the narrowing point of the St. Johns River.