The St George region of Sydney is part of the southern suburbs of Sydney, in the state of New South Wales, Australia. The area includes all the suburbs in the local government area of Georges River Council and the part of Bayside Council which was Rockdale City prior to 2016. This is everything within the boundaries of Salt Pan Creek to the west, The Georges River to the south, Botany Bay to the east and the M5 Motorway and Wolli Creek to the north. This area corresponds to the southern portion of the cadastral Parish of St George, from which the region derives its name and the area was later covered by the St George County Council, the electricity supplier for the councils in this region. This southern portion of the parish below The M5 and Wolli Creek is the more contemporary definition of The St George Region that is considered part of Southern Sydney.

Southern Sydney is the southern metropolitan area of Greater Sydney, in the state of New South Wales, Australia.