Susan Delfino is a fictional character played by Teri Hatcher on the ABC television series Desperate Housewives. The character was created by television producer and screenwriter Marc Cherry. She first appeared in the pilot episode of the series on October 3, 2004, and appeared in every episode until the series finale on May 13, 2012. Susan resides on the fictional Wisteria Lane in Fairview, Eagle State, the primary setting of the show. One of four lead characters, Susan is characterized as being a "notoriously clumsy" romantic with a "magnetic charm." Her storylines tend to focus on her romantic relationships, most notably with Mike Delfino, whom she marries twice in the series.

Teri Lynn Hatcher is an American actress and singer best known for her portrayals of Lois Lane on the television series Lois & Clark: The New Adventures of Superman (1993–1997), Paris Carver in the James Bond film Tomorrow Never Dies (1997), Mel Jones and the Beldam in Coraline (2009), and Susan Mayer on the television series Desperate Housewives (2004–2012), for which she won the Golden Globe Award for Best Actress in a Musical or Comedy and three Screen Actors Guild Awards, and was nominated for a Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series.