Tanintharyi Region is a region of Myanmar, covering the long narrow southern part of the country on the northern Malay Peninsula, reaching to the Kra Isthmus. It borders the Andaman Sea to the west and the Tenasserim Hills, beyond which lie Thailand, to the east. To the north is the Mon State. There are many islands off the coast, the large Mergui Archipelago in the southern and central coastal areas and the smaller Moscos Islands off the northern shores. The capital of the division is Dawei (Tavoy). Other important cities include Myeik (Mergui) and Kawthaung. The division covers an area of 43,344.9 square kilometres (16,735.6 sq mi), and had a population of 1,406,434 at the 2014 Census.

Burmese is a Sino-Tibetan language spoken in Myanmar, where it is the official language, lingua franca, and the native language of the Bamar, the country's principal ethnic group. Burmese is also spoken by the indigenous tribes in Chittagong Hill Tracts in Bangladesh, and in Tripura state in India. The Constitution of Myanmar officially refers to it as the Myanmar language in English, though most English speakers continue to refer to the language as Burmese, after Burma—a name with co-official status that had historically been predominantly used for the country. Burmese is the most widely-spoken language in the country, where it serves as the lingua franca. In 2007, it was spoken as a first language by 33 million. Burmese is spoken as a second language by another 10 million people, including ethnic minorities in Myanmar like the Mon and also by those in neighboring countries. In 2022, the Burmese-speaking population was 38.8 million.