Tate County is a county located in the northwestern portion of the U.S. state of Mississippi. As of the 2020 census, the population was 28,064. Its county seat is Senatobia. Organized in 1873 during the Reconstruction era, from portions of DeSoto, Marshall, and Tunica counties, the county is named for Thomas Simpson Tate, one of the first prominent American settlers of the area.

The Memphis–Clarksdale-Forrest City Combined Statistical Area, TN–MS–AR (CSA) is the commercial and cultural hub of the Mid-South or Ark-Miss-Tenn. The census-defined combined statistical area covers eleven counties in three states, Tennessee, Mississippi, and Arkansas. As of 2020 census, the Memphis metropolitan area had a population of 1,389,905 The Forrest City, Arkansas Micropolitan area was added to the Memphis area in 2012 to form the Memphis–Forrest City Combined Statistical area. In 2023 the Clarksdale, Mississippi Micropolitan area was also added to form the new Memphis-Clarksdale-Forrest City Combined Statistical Area which as of 2023 had a population of roughly 1.4 million people according to census estimates.