The Templo Mayor was the main temple of the Mexica people in their capital city of Tenochtitlan, which is now Mexico City. Its architectural style belongs to the late Postclassic period of Mesoamerica. The temple was called Huēyi Teōcalli in the Nahuatl language. It was dedicated simultaneously to Huitzilopochtli, god of war, and Tlaloc, god of rain and agriculture, each of which had a shrine at the top of the pyramid with separate staircases. The central spire was devoted to Quetzalcoatl in his form as the wind god, Ehecatl. The Great Temple devoted to Huitzilopochtli and Tlaloc, measuring approximately 100 by 80 m at its base, dominated the Sacred Precinct. Construction of the first temple began sometime after 1325, and it was rebuilt six times. The temple was almost totally destroyed by the Spanish in 1521, and the Mexico City cathedral was built in its place.

The Mexica are a Nahuatl-speaking people of the Valley of Mexico who were the rulers of the Triple Alliance, more commonly referred to as the Aztec Empire. The Mexica established Tenochtitlan, a settlement on an island in Lake Texcoco, in 1325. A dissident group in Tenochtitlan separated and founded the settlement of Tlatelolco with its own dynastic lineage. In 1521, their empire was overthrown by an alliance of Spanish conquistadors and rival indigenous warriors, led by the Tlaxcaltec leader Xicotencatl the Elder and the Spaniard Hernán Cortés. The Mexica were subjugated under the Kingdom of Spain for 300 years, until the Mexican War of Independence in 1821.