The Golden Spiders: A Nero Wolfe Mystery is a 2000 American crime drama television film based on the 1953 novel by Rex Stout. Set in 1950s Manhattan, it stars Maury Chaykin as the heavyweight detective genius Nero Wolfe, and Timothy Hutton as Wolfe's assistant, Archie Goodwin, narrator of the Nero Wolfe stories. Veteran screenwriter Paul Monash adapted the novel, and Bill Duke directed. When it first aired on A&E on March 5, 2000, The Golden Spiders was seen in 3.2 million homes, making it the fourth-most-watched A&E original movie ever. Its success led to the A&E original series A Nero Wolfe Mystery (2001–2002).

The Golden Spiders is a Nero Wolfe detective novel by Rex Stout. It was first published in 1953 by The Viking Press.