The Outlaws Is Coming is the sixth and final theatrical comedy starring The Three Stooges after their 1959 resurgence in popularity. By this time, the trio consisted of Moe Howard, Larry Fine, and Joe DeRita. Like its predecessor, The Three Stooges Go Around the World in a Daze, the film was co-written, produced and directed by Moe's son-in-law, Norman Maurer. The supporting cast features Adam West, Nancy Kovack, and Emil Sitka, the latter in three roles.

The Three Stooges were an American vaudeville and comedy team active from 1922 until 1970, best remembered for their 190 short-subject films by Columbia Pictures. Their hallmark styles were physical, farce, and slapstick comedy. Six total Stooges appeared over the act's run ; Moe Howard and Larry Fine were mainstays throughout the ensemble's nearly 50-year run, while the "third stooge" was played in turn by Shemp Howard, Curly Howard, Shemp Howard again, Joe Besser, and "Curly Joe" DeRita.