"The Sixth Extinction II: Amor Fati" is the second episode of the seventh season of the American science fiction television series The X-Files. It was directed by Michael Watkins and written by lead actor David Duchovny and series creator Chris Carter. The installment explores the series' overarching mythology and concludes a trilogy of episodes revolving around Fox Mulder's (Duchovny) severe reaction to an alien artifact. Originally aired by the Fox network on November 14, 1999, "The Sixth Extinction II: Amor Fati" received a Nielsen rating of 10.1 and was seen by 16.15 million viewers. Initial reviews were mixed, and the plot and dialogue attracted criticism. Later critics viewed the episode in a more positive light, and several writers named it among the best in the series.

The seventh season of the American science fiction television series The X-Files commenced airing on the Fox network in the United States on November 7, 1999, concluded on May 21, 2000, and consists of twenty-two episodes. Taking place after the destruction of the Syndicate, this season marks the end of various other story lines; during this season, Fox Mulder learned the true fate of his sister, Samantha.