Thomas Wolsey was an English statesman and Catholic cardinal. When Henry VIII became King of England in 1509, Wolsey became the king's almoner. Wolsey's affairs prospered and by 1514 he had become the controlling figure in virtually all matters of state. He also held important ecclesiastical appointments. These included the Archbishop of York—the second most important role in the English church—and that of papal legate. His appointment as a cardinal by Pope Leo X in 1515 gave him precedence over all other English clergy.

A cardinal is a senior member of the clergy of the Catholic Church. Cardinals are created by the pope and typically hold the title for life. Collectively, they constitute the College of Cardinals. The most solemn responsibility of the cardinals is to elect a new pope in a conclave, almost always from among themselves, when the Holy See is vacant. During the period between a pope's death or resignation and the election of his successor, the day-to-day governance of the Holy See is in the hands of the College of Cardinals. The right to participate in a conclave is limited to cardinals who have not reached the age of 80 years by the day the vacancy occurs. In addition, cardinals collectively participate in papal consistories, in which matters of importance to the Church are considered and new cardinals may be created. Cardinals of working age are also appointed to roles overseeing dicasteries of the Roman Curia, the central administration of the Catholic Church.