The Tunica people are a group of linguistically and culturally related Native American tribes in the Mississippi River Valley, which include the Tunica ; the Yazoo; the Koroa ; and possibly the Tioux. They first encountered Europeans in 1541 – members of the Hernando de Soto expedition.

The Tunica-Biloxi Indian Tribe, formerly known as the Tunica-Biloxi Indian Tribe of Louisiana, is a federally recognized tribe of primarily Tunica and Biloxi people, located in east central Louisiana. Descendants of Ofo (Siouan-speakers), Avoyel, and Choctaw (Muskogean) are also enrolled in the tribe.